国产日产欧美精品-亚洲国产综合久久精品-色综合色国产热无码一-亚洲欧美日本国产,免费观看一区二区三区_在线观看片A免费不卡观看_亚洲а∨天堂久久精品_99久无码中文字幕一本久道

產(chǎn)品展廳收藏該商鋪

您好 登錄 注冊

當(dāng)前位置:
美國布魯克海文儀器公司>技術(shù)文章>ZetaPALS測量應(yīng)用案例-2016-23

技術(shù)文章

ZetaPALS測量應(yīng)用案例-2016-23

閱讀:434          發(fā)布時(shí)間:2016-6-20

文獻(xiàn)名: Preparation, characterization and in vitro photodynamic therapy of a pyropheophorbide-a-conjugated Fe3O4 multifunctional magnetofluorescence photosensitizer

 

作者 Jianjun Cheng,a   Guanghui Tan,ab   Wenting Li,a   Jinghua Li,a   Zhiqiang Wanga and    Yingxue Jina  

a Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin, China

b College of Life Science and Technology, Harbin Normal University, Harbin, China

 

 

摘要:Novel pyropheophorbide-a-conjugated multifunctional magnetofluorescence nanoparticles Fe3O4@SiO2@APTES@Glutaryl-PPa (MFNPs) with a mean diameter of 50 nm were strategically designed and prepared for photodynamic therapy (PDT) and medical fluorescence imaging. Chlorin photosensitizer pyropheophorbide-a (PPa) was covalently anchored on the surface of core–shell Fe3O4@SiO2@APTES nanoparticles that were prepared via a sol–gel process with a bridging glutaryl group. The phase constitution, morphology, size, chemical properties, magnetic property of the intermediates and final nanoparticles were characterized by X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectrometer, zeta potential, vibration sample magnetometer, thermogravimetric analysis, ultraviolet-visible absorption spectra and fluorescent emission spectroscopy. These results showed that the MFNPs have good dispersibility in alcohol and water, excellent magnetization with 17.31 emu g−1 at 300 K, strong superparamagnetic and good photoluminescence property. The in vitro PDT against the human HeLa cervical cancer cell suggested that MFNPs could permeate the tumor cells quickly and possess suitable lipo-hydro partition coefficient, inducing damage and apoptotic cell death. The cancer cell viability was lowered to 10.18% after treatment with PDT. In addition, the formation of reactive oxygen species in HeLa cells after MFNPs-PDT treatment was studied, which suggested that Type I and Type II photodynamic reactions can occur simultaneously.

 

 

收藏該商鋪

登錄 后再收藏

提示

您的留言已提交成功!我們將在第一時(shí)間回復(fù)您~

對比框

產(chǎn)品對比 產(chǎn)品對比 聯(lián)系電話 二維碼 意見反饋 在線交流

掃一掃訪問手機(jī)商鋪
010-62081908
在線留言
南岸区| 昭通市| 洪江市| 油尖旺区| 随州市| 安西县| 竹北市| 鹿邑县| 广平县| 淮阳县| 花莲市| 萝北县| 福海县| 美姑县| 张北县| 丁青县| 从江县| 陆川县| 揭阳市| 龙口市| 红安县| 平昌县| 嘉定区| 藁城市| 铅山县| 图片| 江口县| 桂东县| 禄劝| 东乡县| 太湖县| 杭锦后旗| 陕西省| 金湖县| 大荔县| 勐海县| 镇安县| 湘潭县| 潍坊市| 黑河市| 平凉市|