国产日产欧美精品-亚洲国产综合久久精品-色综合色国产热无码一-亚洲欧美日本国产,免费观看一区二区三区_在线观看片A免费不卡观看_亚洲а∨天堂久久精品_99久无码中文字幕一本久道

產(chǎn)品展廳收藏該商鋪

您好 登錄 注冊

當前位置:
美國布魯克海文儀器公司>技術(shù)文章>Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers

技術(shù)文章

Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers

閱讀:319          發(fā)布時間:2017-8-17
 作者 João Hélio Venâncio, Lígia Marquez Andrade, Najla Locali Santos Esteves, Lara Barroso Brito, Marize Campos Valadares, Gisele Augusto Rodrigues Oliveira, Eliana Martins Lima, Ricardo Neves Marreto, Tais Gratieri, Stephânia Fleury Taveira

 

 

摘要:

Objectives

 

This work aimed to evaluate semisolid formulations containing topotecan (TPT) loaded nanostructured lipid carriers (NLC) for topical treatment of skin cancers, as TPT is effective against a variety of tumours. A formulation which increases TPT skin permeation would be extremely desirable.

Methods

 

TPT-NLC were prepared and incorporated in hydrogels with hydroxyethyl cellulose and chitosan (TPT-NLC-HEC and TPT-NLC-Ch, respectively). Control formulations were obtained by dispersing TPT in HEC and Ch hydrogels (TPT-HEC and TPT-Ch).

Key findings

 

TPT-NLC-HEC and TPT-NLC-Ch showed to maintain the drug and nanoparticle dispersions stable for up to 30 days. When nanoparticles were incorporated into gels, TPT release was significantly decreased (P < 0.05). Still, TPT-NLC-HEC increased 2.37 times permeation compared with TPT-HEC (11.9 and 5.0 μg/cm2, respectively). Cell culture experiments with B16F10 melanoma demonstrated that nanoencapsulation significantly increased TPT cytotoxicity (P < 0.05). TPT-NLC was more toxic than free TPT, with IC50 value of 5.74 μg/ml, whereas free TPT had an IC50 > 20 μg/ml. As skin permeated values of TPT from developed formulation (TPT-NLC) were superior to melanoma IC50, it can be extrapolated that chemotherapeutic permeated amounts may be sufficient for a therapeutic effect.

Conclusions

 

TPT-NLC-HEC may be a valuable tool for the topical treatment of skin cancers.

收藏該商鋪

登錄 后再收藏

提示

您的留言已提交成功!我們將在第一時間回復您~

對比框

產(chǎn)品對比 產(chǎn)品對比 聯(lián)系電話 二維碼 意見反饋 在線交流

掃一掃訪問手機商鋪
010-62081908
在線留言
通道| 阿瓦提县| 千阳县| 武义县| 嵊州市| 武强县| 兴和县| 营口市| 南充市| 双流县| 金堂县| 景东| 桑日县| 曲麻莱县| 叶城县| 尼玛县| 贡山| 龙海市| 武宁县| 南昌县| 长子县| 江孜县| 秭归县| 都兰县| 利津县| 苍南县| 荣成市| 灵石县| 沛县| 河南省| 东安县| 无棣县| 清河县| 长寿区| 任丘市| 盐亭县| 永宁县| 陈巴尔虎旗| 曲周县| 织金县| 建德市|