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美國(guó)布魯克海文儀器公司>技術(shù)文章>Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepe

技術(shù)文章

Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepe

閱讀:476          發(fā)布時(shí)間:2016-8-29

作者 Juan Wu, Wei Jiang, Yewen Shen, Wei Jiang, Renbing Tian

National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing 210094, China

 

摘要:Multifunctional nanocarriers based on the Fe3O4 nanoparticles core and mesoporous silica shell (mSiO2) were synthesized for controlled drug release through magnetic targeting and pH-sensitive performances. The developed Fe3O4@mSiO2 nanocarriers exhibited a suitable size (63 nm) and good magnetic responsibility, doxorubicin (DOX) could be successfully loaded into the mesoporous of Fe3O4@mSiO2 via electrostatic interaction, and the drug loading content and loading efficiency are 29.3% and 93.6%, respectively. The chitosan (CS) was employed to wrap the Fe3O4@mSiO2-DOX as the blocking agent to inhibit premature drug release, and the final CS/Fe3O4@mSiO2-DOX exhibited excellent pH-sensitivity, 86.1% DOX was released within 48 h at pH 4.0. Furthermore, all the release behaviors fit the Higuchi model very well and a purely diffusion-controlled process played a major role on DOX release from CS/Fe3O4@mSiO2-DOX. In addition, MTT assays in human liver hepatocellular carcinoma cells (HepG2) demonstrated that the CS/Fe3O4@mSiO2-DOX had high anti-tumor activity, while the Fe3O4@mSiO2 nanocarriers were practically non-toxic. Thus, our results revealed that the CS/Fe3O4@mSiO2-DOX could play an important role in the development of intracellular delivery nanodevices for cancer therapy.

 

關(guān)鍵詞:Fe3O4; Mesoporous silica; Chitosan; Doxorubicin; pH-sensitive; Targeted cancer therapy

 

 

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