產(chǎn)品描述

生物素 Picolyl 疊氮 是一種先進的生物素探針，它結(jié)合了銅螯合基序，可提高反應(yīng)位點 Cu（I） 的有效濃度，從而提高 CuAAC 反應(yīng)的效率，從而獲得更快、更具生物相容性的 CuAAC 標(biāo)記。據(jù)報道，與傳統(tǒng)疊氮化物相比，信號強度增加了 40 倍（參見精選參考文獻(xiàn)）。

Description

Biotin Picolyl Azide is an advanced biotin probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site to boosted the efficiency of the CuAAC reaction resulting in a faster and more biocompatible CuAAC labeling. Up to 40-fold increase of signal intensity, compared to conventional azides was reported (see Selected References).

產(chǎn)品參數(shù)

化學(xué)結(jié)構(gòu)

精選文選

1.Wood, T. M., et al. (2021). Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol.,

2. Banerjee, A.K.,et al. (2020). SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cells.,

3. Gaebler, A.,et al. (2016). A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J. Lipid. Res., 57, 1934-47.

4. Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem.,, 25, 698-706.

5. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,., 51, 5852-56.