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The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Go

閱讀：312 發(fā)布時(shí)間：2018-01-16

The environmental risk of phthalic acid esters (PAEs) is of great concern. We investigated the reproductive impairment of di-(2-ethylhexyl)-phthalate (DEHP) on Chinese rare minnow, an endemic fish inhabiting the upper streams of the Yangtze River. Chinese rare minnow larvae were exposed to environmentally relevant concentrations of DEHP (0, 4.2, 13.3, and 40.8 mg/L) for 6 months. Plasma testosterone and 17b-estradiol levels decreased in females, accompanied by downregulation of cyp19a and cyp17 gene transcription in ovary. Increases in plasma testosterone concentration were observed in males, accompanied by downregulation of cyp19a gene transcription in testes. Hepatic VTG gene transcription was upregulated in males and females. Exposure to DEHP reduced egg production and inhibited oocyte maturation in females and retarded spermiation in males. Decreased egg protein content was measured in F1 embryos. These results indicate that long-term exposure to low concentrations of DEHP (13.3 mg/L) causes endocrine disruption and impairs fish reproduction.（鄰苯二甲酸酯引起的環(huán)境風(fēng)險(xiǎn)是非常值得關(guān)注的。我們研究了鄰苯二甲酸二酯對(duì)中國(guó)稀有魚(yú)類鰷魚(yú)造成的生殖損傷,這種魚(yú)生活在長(zhǎng)江的上游。中國(guó)稀有鰷魚(yú)小魚(yú)苗在鄰苯二甲酸二酯濃度分別為(0, 4.2, 13.3, and 40.8 mg/L)的環(huán)境下六個(gè)月。雌魚(yú)的血漿睪酮和17β雌二醇水平降低,連同卵巢上的cyp19a 和cyp17基因轉(zhuǎn)錄也有所下降。雄魚(yú)中血漿睪酮濃度增加,連同睪丸上的cyp19a基因轉(zhuǎn)錄也有所下降。雌雄魚(yú)中的肝VTG基因轉(zhuǎn)錄上調(diào)。在鄰苯二甲酸二酯環(huán)境中,減少了卵子的產(chǎn)生,抑制了雌性卵細(xì)胞的成熟,延緩了雄性精子的發(fā)育。在F1胚胎中蛋白含量減少。這些結(jié)果顯示長(zhǎng)期接觸低濃度鄰苯二甲酸二酯(13.3 mg/L)能引起魚(yú)類的內(nèi)分泌失調(diào)和損害魚(yú)的繁殖。）

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The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Go

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