Genetically engineered HEK293 cells expressing the firefly luciferase gene under the control of Nuclear factor-κB (NF-κB) Response Elements and with constitutive expression of human RANK (Receptor activator of nuclear factorκB; TNFRSF11A; ref. seq. NM_003839.2). Overexpression of RANK was confirmed by flow cytometry and the cell line was functionally validated for its response to RANK ligａnd (RANKL).

Activation of NF-κB-dependent luciferase reporter in the RANK/NF-κB Luciferase Reporter HEK293 Cell Line. Created with BioRender.com.

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