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BPS Bioscience Inc.
中級會員 | 第3年

當(dāng)前位置:BPS Bioscience Inc.>>細(xì)胞庫 / 細(xì)胞培養(yǎng)>> GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

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更新時(shí)間:2023-10-12 09:30:17瀏覽次數(shù):247次

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  • 數(shù)量:

    1

  • 供應(yīng)商:

    BPS Bioscience

  • 細(xì)胞類型:

    穩(wěn)轉(zhuǎn)細(xì)胞系

  • 品系:

    HeLa

  • 組織來源:

    /

  • 相關(guān)疾?。?/span>

    多種

  • 物種來源:

    human

  • 免疫類型:

    多種

  • 器官來源:

  • 運(yùn)輸方式:

    干冰

  • 年限:

    10

  • 生長狀態(tài):

    良好

  • CAS號:

  • 英文名:

    GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

  • 注冊證號:

    /

  • 規(guī)格:

    2管

The GAS reporter (Luc)-HeLa cell line is designed to monitor the activity of interferon gamma-induced signal transduction pathways in cultured cells by measuring activated STAT1 homodimers. It contains a firefly luciferase gene driven by three copies of the interferon gamma-activated sites (GAS) located upstream of the minimal TATA promoter. IFNγ first binds to a heterodimeric receptor consisting of two chains, IFNGR1 and IFNGR2, causing its dimerization and the activation of specific Janus family kinases (JAK1 and JAK2). Two STAT1 molecules associate with this ligand-activated receptor complex and are activated by phosphorylation to form active homodimer. The active STAT1 homodimers translocate to the nucleus where they bind interferon gamma-activated sites (GAS) in the promoter of IFNγ inducible genes, including luciferase reporter gene.

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