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Ramelteon

CAS No. : 196597-26-9

MCE 國(guó)際站：Ramelteon

產(chǎn)品活性：Ramelteon 是一種強(qiáng)效、高選擇性和具有口服活性的 MT1/MT2 激動(dòng)劑，Ki 值分別為 14 和 112 pM。Ramelteon 具有研究失眠癥的潛力。Ramelteon長(zhǎng)期使用持續(xù)減少睡眠發(fā)作，停藥后無(wú)翌日晨殘留效應(yīng)或反彈性失眠或戒斷癥狀。

研究領(lǐng)域：GPCR/G Protein  |  Neuronal Signaling

作用靶點(diǎn)：Melatonin Receptor

In Vivo: Ramelteon (p.o.; 0.1 and 1 mg/kg) accelerates reentrainment of running wheel activity rhythm to the new lightdark cycle.
Ramelteon (p.o.; 3, 10, and 30 mg/kg) does not affect learning or memory in rats tested by the water maze task and the delayed match to position task, implying that MT1/MT2 receptor agonists have no abuse potential.
Ramelteon (0.0001, 0.001, 0.01, and 0.1 mg/kg; p.o.; 8 hours) significantly decreases wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, increases slow-wave sleep at doses of 0.001, 0.01, and 0.1 mg/kg, and increases rapid eye movement sleep at a dose of 0.1 mg/kg.

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