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Norbinaltorphimine dihydrochloride

CAS No. : 113158-34-2

產(chǎn)品活性：Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist.

研究領(lǐng)域：GPCR/G Protein  |  Neuronal Signaling

作用靶點：Opioid Receptor

In Vitro: Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.

In Vivo: Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.

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