目錄:MedChemExpress LLC>>生化試劑>> Capromorelin Tartrate | MCE
| CAS | 193273-69-7 | 純度 | 98.71% |
|---|---|---|---|
| 分子量 | 655.7 | 分子式 | C??H??N?O?? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 2 mg |
| 貨號 | HY-15243 | 應用領域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
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CAS No. : 193273-69-7
產(chǎn)品活性：Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.
研究領域：GPCR/G Protein
作用靶點：GHSR
In Vitro: Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM.
In Vivo: Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.
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