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Xanomeline

CAS No. : 131986-45-3

產(chǎn)品活性：Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

研究領(lǐng)域：GPCR/G Protein  |  Neuronal Signaling

作用靶點：mAChR

In Vitro: Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current.

In Vivo: Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys.
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile.Xanomeline inhibits D-amphetamine- and (?)-apomorphine-induced behavior and do not cause extrapyramidal side effects.

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