目录:MedChemExpress LLC>>生化试剂>> Ertapenem disodium | MCE
CAS | 153832-38-3 | 分子量 | 519.48 |
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分子式 | C??H??N?Na?O?S | 供货周期 | 现货 |
货号 | HY-A0294A | 应用领域 | 医疗卫生,化工,生物产业,制药/生物制药 |
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CAS No. : 153832-38-3
产品活性:Ertapenem (MK-0826) disodium is a broad spectrum and long acting β-lactam antibiotic. Ertapenem disodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem disodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract.
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Ertapenem disodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively.
In Vivo: Ertapenem disodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log10 CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.Ertapenem disodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of <0.25 mg/kg/dose.
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