国产日产欧美精品-亚洲国产综合久久精品-色综合色国产热无码一-亚洲欧美日本国产,免费观看一区二区三区_在线观看片A免费不卡观看_亚洲а∨天堂久久精品_99久无码中文字幕一本久道

武漢原生原代生物醫(yī)藥科技有限公司

賀中國科學院工程研究所和清華大學生命科學學院應用PriCe

時間:2021-09-06
分享:

  
賀中國科學院工程研究所和清華大學生命科學學院應用PriCells產品/技術服務發(fā)表文章
 
Activated Scavenger Receptor A Promotes Glial Internalization of Ab
 
PLOS ONE Published: April 09,2014 DOI:10.1371/journal.pone.0094197
 
He Zhang1,2, Ya-jing Su3, Wei-wei Zhou1, Shao-wei Wang1, Peng-xin Xu1, Xiao-lin Yu1*, Rui-tian Liu1*
 
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China,
Tsinghua University School of Medicine, Haidian District, Beijing, China, 
3 School of Life Science, Ningxia University, Yinchuan, China
 
Abstract
Beta-amyloid (Aβ) aggregates have a pivotal role in pathological processing of Alzheimer’s disease (AD). The clearance of Aβ monomer or aggregates is a causal strategy for AD treatment. Microglia and astrocytes are the main macrophages that exert critical neuroprotective roles in the brain. They may effectively clear the toxic accumulation of Aβ at the initial stage of AD, however, their functions are attenuated because of glial overactivation. In this study, we first showed that heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Aβ to SR-A, thereby promoting glial phagocytosis of Aβ oligomer in microglia and astrocytes and triggering intracellular mitogen-activated protein kinase (MAPK) signaling cascades. Moreover, XD4 enhances the internalization of Aβ monomers to microglia and astrocytes through macropinocytosis or SR-A-mediated phagocytosis. Furthermore, XD4 significantly inhibits Aβ oligomer-induced cytotoxicity to glial cells and decreases the production of proinflammatory cytokines, such as TNF-α and IL-1β, in vitro and in vivo. Our findings may provide a novel strategy for AD treatment by activating SR-A.
 
MIC-CELL-0077 / MED-0014,PriCells



會員登錄

×

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

X
該信息已收藏!
標簽:
保存成功

(空格分隔,最多3個,單個標簽最多10個字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時間回復您~
撥打電話 產品分類
在線留言
萨迦县| 太仓市| 龙里县| 抚顺市| 临安市| 馆陶县| 安泽县| 阳山县| 理塘县| 巫溪县| 弥渡县| 莱西市| 新民市| 九龙县| 鹤岗市| 攀枝花市| 西乡县| 茌平县| 平舆县| 绥德县| 昌宁县| 新宾| 和静县| 西青区| 景洪市| 环江| 阿克陶县| 苗栗县| 安岳县| 舞阳县| 连城县| 宜宾市| 兴和县| 探索| 辽阳市| 大同县| 浠水县| 灌云县| 高陵县| 长岛县| 宜昌市|