粘蛋白（MUC1）重组蛋白

广州健仑生物科技有限公司

粘蛋白1又称多形性上皮粘蛋白，属于粘蛋白家族成员。该抗体主要表达与乳腺癌、胃肠道、呼吸道和泌尿生殖道的上皮细胞。

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粘蛋白（MUC1）重组蛋白

【产品介绍】

细胞定位：细胞浆

克隆号：MRQ-17

同型：IgG

适用组织：石蜡/冰冻

阳性对照：乳腺/乳腺癌

抗原修复：热修复（EDTA）

抗体孵育时间：60min

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【公司名称】 广州健仑生物科技有限公司
【市场部】     欧

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

该研究的主要作者Marco Demaria博士使用了两种不同的小鼠模型：*种，衰老细胞可以可视化，能在活动物体内被消除;第二种，小鼠体内两个关键基因的突变阻止衰老程序。
Demario发现，小鼠皮肤出现伤口后，那些产生胶原蛋白和位于血管内的细胞更早就发生了衰老。按Demaria所述，衰老细胞通过分泌PDGF-AA加速伤口闭合，PDGF-AA是存在于血小板内的生长因子。我们能够应用重组PDGF-AA到创伤小鼠，恢复小鼠的伤口愈合。
研究人员还发现，衰老细胞在组织修复过程中仅存在一个很短的时间，而相比之下，在老化或慢性损伤组织中，衰老细胞持久存在。此外，他们说，事实上，在体外诱导细胞衰老实验中，PDGF-AA是非常早的活化，表明该分泌因子随时间变化而发挥不同的调节功能的可能性，这就可以部分解释衰老细胞的有益与有害作用。
罗切斯特大学研究人员认为，他们在解决体重增加奥秘的机制中获得重大突破。他们发现一种蛋白质Thy1在控制一个原始细胞是否决定成为脂肪细胞中有一个基本的作用，这就使得Thy1成为一个可能的治疗目标，相关研究已经发表在FASEB Journal上。

Dr. Marco Demaria, the lead author of the study, used two different mouse models: first, the aged cells were visualized and eliminated in the living body; second, mutations in two key genes in the mouse prevented aging program.
Demario found that those cells that produce collagen and are located inside the bloodstream senesce earlier, as soon as wounds develop on the skin of mice. As Demaria states, senescent cells accelerate wound closure by secreting PDGF-AA, a growth factor present in plaets. We were able to apply recombinant PDGF-AA to trauma mice to restore wound healing in mice.
The researchers also found that senescent cells exist only for a short period of time in the process of tissue repair, whereas senescent cells persist in aging or chronic injury tissues. In addition, they say, in fact, that PDGF-AA is a very early activation in in vitro-induced cellular senescence experiments, suggesting the potential for this secretion factor to exert different regulatory functions over time, which may in part explain the effects of senescent cells Beneficial and harmful effects.
Researchers at the University of Rochester believe they have made a major breakthrough in the mechanics of tackling the mysteries of weight gain. They found Thy1, a protein that plays a fundamental role in controlling whether a primordial cell decides to become a fat cell, makes Thy1 a potential therapeutic target, a study already published in the FASEB Journal.