详细介绍
Ki67 细胞增殖指数(克隆号:MIB-1)
广州健仑生物科技有限公司
Ki-67抗原是一种与细胞增殖特异相关的核抗原,主要用于研究细胞增殖活性。Ki-67在所有细胞周期活动期(G1晚期、S、G2和M期)的增殖细胞中表达,但在静止细胞中不表达。
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Ki67 细胞增殖指数(克隆号:MIB-1)
【产品介绍】
细胞定位:细胞浆
克隆号:SP6
同型:IgG1
适用组织:石蜡/冰冻
阳性对照:扁桃体/乳腺癌
抗原修复:热修复(EDTA)
抗体孵育时间:30-60min
产品编号 | 抗体名称 | 克隆型别 |
OB141 | IMP3(胰岛素样生长因子2mRNA结合蛋白3) | 69.1 |
OB142 | IMP3(胰岛素样生长因子2mRNA结合蛋白3) | EP286 |
OB143 | Inhibin α(抑制素 α) | R1 |
OB144 | INI-1(整合酶互动者1) | MRQ-27 |
OB145 | Kappa(κ轻链) | HP6053 |
OB146 | Ki67(细胞增殖指数) | SP6 |
OB147 | Ki67(细胞增殖指数) | MIB-1 |
OB148 | Ksp-Cadherin(肾特异性钙粘附蛋白) | MRQ-33 |
OB149 | Lambda(λ轻链) | HP6054 |
OB150 | Laminin(层黏连蛋白) | LAM-89 |
OB151 | Langerin(朗格素) | 12D6 |
OB152 | LH(促黄体生成激素) | polyclonal |
OB153 | LRP(肺癌耐药蛋白) | 1032 |
OB154 | Lysozyme(溶菌酶) | polyclonal |
OB155 | Mammaglobin cocktail (乳腺球蛋白) | 304-1A5 & 31A5 |
OB156 | MART-1/Melan-A(黑色素A) | A103 |
OB157 | MBP(髓磷脂碱性蛋白) | polyclonal |
OB158 | MCM2(微小染色体维持复合成分2) | CRCT2.1 |
OB159 | MCM2(微小染色体维持复合成分2) | 1E7 |
Ki67
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【公司名称】 广州健仑生物科技有限公司
【市场部】 欧
【】
【腾讯 】
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室
UT西南医学中心细胞生物学副主席Jerry W. Shay教授及其同事、细胞生物学和内科医学教授Woodring E. Wright发现,6-thio-2'-脱氧鸟苷(6-thio-2'-deoxyguanosine)能阻止培养物中癌细胞的生长,并减少小鼠体内肿瘤的生长。
Harold C. Simmons 综合癌症中心副主任Shay博士说:“我们观察到,用很低浓度的6-thiodG,就能有效地对抗一系列癌细胞系,并且减轻小鼠体内的肿瘤负荷。”
相关研究结果发表在zui近的*学术期刊《Cancer Discovery》,本文共同资深作者是Shay和Wright博士。
6-thiodG通过靶定一种*的机制而发挥作用,这种机制被认为可调节细胞的存活时间,是一种衰老时钟。这种生物钟被定义为一种DNA结构,称为端粒,其位于细胞染色体末端,可?;と旧宀皇苌撕Γ康毕赴至咽彼突崴醵?。一旦端粒缩短到临界长度,细胞就不再分裂,并通过一个称为细胞凋亡的过程死亡。
The Ki-67 antigen is a nuclear antigen that is specifically associated with cell proliferation and is used primarily to study cell proliferative activity. Ki-67 is expressed in proliferating cells in all cell cycle phases (late G1, S, G2 and M phases), but not in quiescent cells. Jerry W. Shay, vice president of cell biology at UT Southwestern Medical Center and his colleague Woodring E. Wright, professor of cellular and medical science, found that 6-thio-2'-deoxyguanosine ) Can prevent the growth of cancer cells in culture and reduce the growth of tumors in mice.
"We observed that with a very low concentration of 6-thiodG, we were able to effectively fight a series of cancer cell lines and reduce the tumor burden in mice," said Dr. Shay, associate director of the Harold C. Simmons Comprehensive Cancer Center.
Relevant research results published in the recent top international academic journals Cancer Discovery, co-senior author of this article are Dr. Shay and Wright.
6-thiodG works by targeting a unique mechanism that is thought to regulate cell survival and is an aging clock. This biological clock is defined as a DNA structure called a omere located at the end of a cell's chromosome that protects the chromosome from harm and shortens it whenever the cell divides. Once the omere has shortened to a critical length, the cells no longer divide and die through a process called apoptosis.