Desmin(结蛋白)鼠单克隆抗体

广州健仑生物科技有限公司

Desmin是一种中间丝蛋白，广泛分布于骨骼肌、心肌、平滑肌及肌上皮细胞，其在肿瘤中表达的特点是高分化高表达、低分化低表达。此抗体既可以和人横纹?。ü趋兰『托募。┑慕岬鞍追从?，又可以和平滑肌的结蛋白反应，与其它的中间丝蛋白（如波形蛋白、角蛋白、胶质纤维酸性蛋白、神经丝等）无交叉反应，主要用于骨骼肌、心肌和平滑肌及其来源的肿瘤的研究。

本次研究发现，大肠埃希菌，肠杆菌属，肺炎克雷伯菌的ESBLs的检出率zui高，分别是55.6%，40.0%和25.0%，对这三种细菌抗菌活性zui高的是亚胺培南，哌拉西林—三唑巴坦和头孢吡肟，对产ESBLs菌而言，不同的ESBLs对不同的三代头孢菌素具有不同的活性，某些ESBLs能赋予细菌对所有B-内酰胺类抗生素高水平的耐药，而仅轻微提高耐药性，而头孢噻肟和头孢他啶则是识别不同ESBLs的*底物 。至今为止，亚胺培南仍是作为治ESBLs菌的*药。
嗜麦芽窄食单胞菌也是重症肺炎较常见的多重耐药致病菌，本次监测，除对左氧氟沙星（33.3%）外，对其他抗生素均耐药严重，因其外膜通透性低，且可诱导B-内酰胺类L2、L1存在，所以对B-内酰胺类抗生素，氨基糖甙类，碳青霉烯类均高度耐药，故该菌的感染已成为临床治疗的难题，目前研究发现，复方磺胺甲恶唑和替卡西林-棒酸是治疗嗜麦芽窄食单胞菌感染zui为有效的药物。

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Desmin(结蛋白)鼠单克隆抗体

【产品介绍】

细胞定位：细胞浆

克隆号：D33

同型：IgG1/K

适用组织：石蜡/冰冻

阳性对照：阑尾

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

Desmin(结蛋白)鼠单克隆抗体

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【公司名称】 广州健仑生物科技有限公司
【市场部】     欧

【】 
【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

Desmin is a kind of intermediate silk protein, widely distributed in skeletal muscle, myocardium, smooth muscle and myoepithelial cells. Its expression in tumor is highly differentiated, poorly differentiated and poorly expressed. This antibody not only reacts with desmin in human striated muscle (skeletal muscle and myocardium) but also with desmokinin in smooth muscle, and interacts with other intermediate silk proteins such as vimentin, keratin, glial fibrillary acidic protein, ) No cross-reaction, mainly for skeletal muscle, myocardium and smooth muscle and the tumors of their origin.

The study found that the highest detection rate of Escherichia coli, Enterobacter, Klebsiella pneumoniae ESBLs were 55.6%, 40.0% and 25.0%, the highest antibacterial activity of these three bacteria is imine Penelope, Piperacillin-Tazobactam and Cefepime, for ESBLs-producing bacteria, different ESBLs have different activities on different third-generation cephalosporins and some ESBLs confer bacterial tolerance to all B-lactams Class antibiotics have high levels of resistance but only slightly increased resistance, whereas cefotaxime and ceftazidime are the best substrates for identifying different ESBLs. To date, imipenem is still the drug of choice for the treatment of ESBLs.
Stenotrophomonas maltophilia is also more common in severe pneumonia multi-drug resistant pathogens, the monitoring, except for levofloxacin (33.3%), the other antibiotics are resistant, because of its low permeability of the outer membrane, And can induce B-lactam L2, L1 exists, so the B-lactam antibiotics, aminoglycosides, carbapenems are highly resistant, so the bacteria infection has become a clinical problem, the current The study found that the compound sulfamethoxazole and ticarcillin - clavulanic acid treatment of Stenotrophomonas maltophilia the most effective drug.