Cytokeratin 20(细胞角蛋白20)

广州健仑生物科技有限公司

细胞角蛋白20（CK20）分子量为46KDa，主要研究胃肠道上皮、尿道上皮和Merkel 细胞。主要用于胃肠道肿瘤、泌尿道肿瘤、卵巢黏液性肿瘤和Merkel 细胞癌的研究。鳞癌、乳腺癌、肺癌、子宫内膜癌和卵巢非黏液性肿瘤均不表达CK20。细胞角蛋白19片段（Cytokeratin-19-fragment CYFRA21-1)是肺泡上皮细胞凋亡时，其细胞中含有的角蛋白的碎片降解后变成可溶性物质而进入血液，使血中含量增高。非小细胞肺癌的*标志物。特别是鳞状上皮细胞癌目前*的肿瘤标志物，灵敏度可达60%，特异性可达95%。它对非小细胞肺癌(NSCLC)的早期诊断、疗效监测和预后判断均有重要意义。监测非小细胞肺癌的病程和预后。血中CYFRA21-1水平显著升高提示肿瘤的晚期或预后差；如果对非小细胞肺癌的治疗效果好，其水平会很快下降或恢复到正常水平，如值不变或轻度减低提示肿瘤未*去除或有多发性肿块存在。

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Cytokeratin 20(细胞角蛋白20)

【产品介绍】

细胞定位：细胞浆

克隆号：Ks20.8

同型：IgG2a/K

适用组织：石蜡/冰冻

阳性对照：直肠

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

Cytokeratin 20(细胞角蛋白20)

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【公司名称】 广州健仑生物科技有限公司
【市场部】     欧

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

Cytokeratin 20 (CK20) has a molecular weight of 46 kDa and is mainly studied in the gastrointestinal epithelium, urothelium and Merkel cells. Mainly used for gastrointestinal tumors, urinary tract tumors, ovarian mucinous tumors and Merkel cell carcinoma research. CK20 was not expressed in squamous cell carcinoma, breast cancer, lung cancer, endometrial cancer and ovarian non-mucinous tumors. Cytokeratin 19 fragment (Cytokeratin-19-fragment CYFRA21-1) is alveolar epithelial cell apoptosis, the cells contained in the degradation of keratin fragments become soluble substances into the blood, so that blood levels. Preferred marker for non-small cell lung cancer. In particular squamous cell carcinoma is currently the preferred tumor marker, the sensitivity of up to 60%, the specificity of up to 95%. It is of great importance for the early diagnosis, curative effect monitoring and prognosis judgment of non-small cell lung cancer (NSCLC). Monitor the course and prognosis of non-small cell lung cancer. A significant increase in blood levels of CYFRA21-1 suggests a poor late or poor prognosis of the tumor; if the effect on non-small cell lung cancer is good, the level will rapidly decline or return to normal levels, as invariant or mild decrease in value suggests a tumor Not compley removed or there are multiple bumps.