Cyclin D1(周期素D1)兔单克隆抗体

广州健仑生物科技有限公司

CyclinD1(PRAD-1或bcl-1)是一个重要的细胞周期调节因子，功能与细胞周期素依赖激酶4或细胞周期素依赖激酶6 磷酸化Rb蛋白有关。它是一个有争议的原癌基因,在许多人类肿瘤包括套细胞淋巴瘤中表达。

简单来讲，细胞周期可以分为四个阶段：G0/G1、S、G2及M。G1和G2期是细胞生长期；S期是细胞将细胞核内的染色体复制的时期；M期是细胞进行有丝分裂(mitosis)或减数分裂(meiosis)的时期。
在各个时期各有不同的周期素所调控著，不同的周期素在细胞周期的不同阶段发生作用。细胞周期的主要周期素有：cyclin A, cyclin B, cyclin D及cyclin E。在G1期→S期调控蛋白为细胞周期蛋白D1(cyclin D1)以及细胞周期蛋白E(cyclin E)，s期→G2期调控蛋白为细胞周期蛋白A(cyclin A)，G2期→M期调控蛋白为细胞周期蛋白B(cyclin B)。
每一个周期素都有一个共同位叫cyclin box。cyclin box的功能是激活一种叫周期素激酶(cyclin-dependent kinase; CDK)。
不同的周期素激酶在细胞周期的不同阶段发生作用。例如：cyclin D激活CDK4或CDK6掌控G1期的细胞生长；cyclin A及cyclin E激活CDK2调控染色体复制；cyclin A及cyclin B激活CDK1调控有丝分裂和减数分裂。有趣的是，有些周期素虽然拥有cyclin box但它们没有可激活的CDK：例如cyclin F, cyclin I以及cyclin G。而且cyclin I并没有细胞周期的调控功能，它主要作用在神经细胞上。

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Cyclin D1(周期素D1)兔单克隆抗体

【产品介绍】

细胞定位：细胞核

克隆号：SP4

同型：IgG

适用组织：石蜡/冰冻

阳性对照：套细胞淋巴瘤

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

Cyclin D1(周期素D1)兔单克隆抗体

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【公司名称】 广州健仑生物科技有限公司
【市场部】     欧

【】 
【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

CyclinD1 (PRAD-1 or bcl-1) is an important cell cycle regulator that functions in conjunction with cyclin-dependent kinase 4 or cyclin-dependent kinase 6 phosphorylation of Rb protein. It is a controversial oncogene that is expressed in many human tumors, including mantle cell lymphoma.

In simple terms, the cell cycle can be divided into four stages: G0 / G1, S, G2 and M. The G1 and G2 phases are the cell growth phase; the S phase is the period in which the cells replicate the chromosomes in the nucleus; and the M phase is the period in which the cells undergo mitosis or meiosis.
In different periods of different cyclins regulation, different cyclins in the different stages of the cell cycle play a role. The main cell cycle cycle are: cyclin A, cyclin B, cyclin D and cyclin E. In the G1 phase → S phase, the regulatory proteins are cyclin D1 and cyclin E, and the s-phase → G2-phase regulatory proteins are cyclin A, G2 → M phase regulation The protein is cyclin B.
Every cyclotron has a common denominator called a cyclin box. The function of the cyclin box is to activate a cell cycle called cyclin-dependent kinase (CDK).
Different cyclin kinases act at different stages of the cell cycle. For example, cyclin D activates CDK4 or CDK6 to control G1 cell growth; cyclin A and cyclin E activate CDK2 to regulate chromosome replication; and cyclin A and cyclin B activate CDK1 to regulate mitosis and meiosis. Interestingly, although some cyclin have a cyclin box, they do not have an activatable CDK: cyclin F, cyclin I, and cyclin G, for example. And cyclin I does not have the cell cycle regulatory function, it mainly acts on nerve cells.