CA-125 卵巢癌抗原（克隆M11）

广州健仑生物科技有限公司

CA125是1981年由Bast等从上皮性卵巢癌抗原检测出可被单克隆抗体OC125结合的一种糖蛋白，来源于胚胎发育期体腔上皮，在正常卵巢组织中不存在，因此zui常见于上皮性卵巢肿瘤（浆液性肿瘤）患者的血清中，其诊断的敏感性较高，但特异性较差。黏液性卵巢肿瘤中不存在。80%的卵巢上皮性肿瘤患者血清CA125升高，但近半数的早期病例并不升高，故不单独用于卵巢上皮性癌的早期诊断。90%患者血清CA125与病程进展有关，故多用于病情检测和疗效评估。95%的健康成年妇女CA125的水平≤40U/ml，若升高至正常值的2倍以上应引起重视。另外CA125也可见于结核性腹膜炎患者的血清检查中，且CA125水平呈数十倍升高，在卵巢癌术前应明确排除结核性腹膜炎可能。

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【产品介绍】

细胞定位：细胞浆/细胞膜

克隆号：M11

同型：IgG1/k

适用组织：石蜡/冰冻

阳性对照：卵巢癌/子宫内膜癌

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

CA-125 卵巢癌抗原（克隆M11）

诊断检查
病原体检查
取自患处的标本作直接涂片或培养，涂片可见菌丝或曲霉菌孢子，培养见曲霉菌生长。曲霉菌是实验室常见的污染菌，必须反复涂片或培养，多次阳性且为同一菌种才有诊断价值。
病理组织检查
取受损组织或淋巴结活检，可根据真菌形态确诊。尤其对播散性曲霉菌，可及时作出诊断。
治疗方案
一般治疗
1、积极治疗原发并，去除病因。
2、严格掌握抗生素、糖皮质激素和免疫抑制剂的用药指征，尽可能少用或不用这些药物。
3、加强护理和支持疗法，补充维生素和微量元素。
抗真菌治疗
1、制霉菌素
（1）局部用药：可制成油剂、霜剂、粉剂、溶液等，浓度为含制霉菌素10万U/g或/ml基质，依患者具体情况援用一种剂量一型局部涂擦，每日2—4次。
（2）口服：肠道念珠菌病可给予制霉菌素口服，新生儿每日20—40万U，2岁以下每日40—80万U，2岁以上每日100—200万U，分3—4次饭前服用，疗程7—10日?？诜灰孜?，全部由粪便排出。不良反应有抗原抗体、呕吐、轻泻。
（3）雾化吸入：适用于呼吸系统念珠菌病，制霉菌素5万U溶于2ml0.9%氯化钠溶液中雾化吸入。
2、二性霉素B为多烯类抗生素
与真菌胞膜上的固醇类结合，改变膜的通透性，使菌体破坏，起杀菌作用。是目前治疗隐球菌病、组织胞浆菌病和全身念珠菌病的*药物，对曲霉素菌病效果较差。
（1）静脉滴注：开始义用小量，每日0.1mg/kg，如无不良反应，渐增至每日1—1.5mg/kg，疗程1—3个月。静注时用5%葡萄糖液稀释，浓度不超过0.05—0.1mg/ml，缓慢静脉滴注，每剂不少于6小时滴完。浓度过高易引起静脉炎，滴速过快可发生抽搐，心律时常、血压骤降，甚至心跳停搏。
（2）椎管内注射或脑室内注射：限于治疗隐球菌性膜的病情严重或静脉滴注失败的病例。儿童鞘内注射，*0.1mg用蒸馏水（不用0.9%氯化钠溶液）稀释，浓度不超过0.25mg/ml（偏稀为宜）或将药物与腰穿时引流出的脑脊液3—5md混合后一并缓慢注入。以0.5mg为止不低超过0.7mg。疗程一般约30次，如有副作用可减量或暂停用药，脑脊液内药物过多可引起蛛网膜炎而脑脊液细胞增多，暂时性神经根炎、感觉消失、尿潴留、甚至瘫痪、抽搐，如及早停吆五，大多能缓解。

CA-125

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

想了解更多的产品及服务请扫描下方二维码：

【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

Diagnostic test
Pathogen examination
Specimens taken from the affected area for direct smear or culture, smear mycelium or aspergillus spores can be seen, the culture see Aspergillus growth. Aspergillus is a common laboratory contamination, must be repeated smear or culture, many times positive and for the same species have diagnostic value.
Pathological examination
Take damaged tissue or lymph node biopsy can be confirmed according to the fungal morphology. Especially for disseminated Aspergillus, timely diagnosis can be made.
Treatment programs
General treatment
1, active treatment of primary and remove the cause.
2, strict control of antibiotics, glucocorticoid and immunosuppressive drug indications, as little as possible or without these drugs.
3, to strengthen nursing and supportive therapy, vitamin supplements and trace elements.
Anti-fungal treatment
1, nystatin
(1) topical: can be made of oil, cream, powder, solution, concentration of nystatin containing 10 million U / g or / ml matrix, according to the specific circumstances of patients with reference to a dose of a type of local rubbed, 2-4 times a day.
(2) Oral: Enteric candidiasis can be given nystatin oral, neonates daily 20-40 million U, under the age of 2 40-80 million U daily, more than 2 years of age 100-200 million U, 3-4 times before taking, treatment 7-10 days. Oral absorption is not easy, all excreted by the feces. Adverse reactions with antigen-antibody, vomiting, laxation.
(3) inhalation of atomization: suitable for respiratory candidiasis, nystatin 50000 U dissolved in 2ml0.9% sodium chloride solution atomized inhalation.
2, amphotericin B is a polyene antibiotic
And the fungal membrane steroid binding, change the permeability of the membrane, so that cell damage, play a bactericidal effect. Is currently the treatment of cryptococcosis, histoplasmosis and systemic candidiasis drug of choice, the bad effect on the amyloidosis.
(1) intravenous drip: beginning with a small amount of justice, 0.1mg / kg daily, without adverse reactions, increased to 1-1.5mg / kg daily for 1-3 months. Intravenous with 5% glucose solution dilution, the concentration of not more than 0.05-0.1mg / ml, slow intravenous drip, each dose of not less than 6 hours drip finished. High concentrations can cause phlebitis, rapid drip can occur convulsions, heart rate often, sudden drop in blood pressure, and even cardiac arrest.
(2) spinal canal injection or intracerebroventricular injection: limited to the treatment of cryptococcal disease or intravenous infusion of serious cases of failure. Children intrathecal injection, the first 0.1mg diluted with distilled water (without 0.9% sodium chloride solution), the concentration of not more than 0.25mg / ml (partial dilute appropriate) or the drug and when the cerebrospinal fluid drained out when 3-5md mixed Slowly injected together. To 0.5mg so far not lower than 0.7mg. Treatment is generally about 30 times, if side effects can be reduced or suspended medication, excessive drug in the cerebrospinal fluid can cause arachnoiditis and cerebrospinal fluid cells increased, temporary nerve root inflammation, feeling disappeared, urinary retention, or even paralysis, convulsions, such as early Stop five, most can ease.