仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用. Denosumab （anti-RANK ligand） （AMG-162, Prolia, Xgeva） is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL （143–317） to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.