仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用. Dalotuzumab （MK-0646） is a recombinant humanized monoclonal antibody （IgG1 type） targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo