国产日产欧美精品-亚洲国产综合久久精品-色综合色国产热无码一-亚洲欧美日本国产,免费观看一区二区三区_在线观看片A免费不卡观看_亚洲а∨天堂久久精品_99久无码中文字幕一本久道

深圳欣博盛生物科技有限公司
中級(jí)會(huì)員 | 第5年

13129540117

當(dāng)前位置:深圳欣博盛生物科技有限公司>>天然免疫研究產(chǎn)品>> MPLA Synthetic VacciGrade™

MPLA Synthetic VacciGrade™

參   考   價(jià): 3060

訂  貨  量: ≥1  件

具體成交價(jià)以合同協(xié)議為準(zhǔn)

產(chǎn)品型號(hào)

品       牌Invivogen

廠商性質(zhì)代理商

所  在  地深圳市

更新時(shí)間:2022-01-29 09:38:39瀏覽次數(shù):988次

聯(lián)系我時(shí),請(qǐng)告知來自 化工儀器網(wǎng)
同類優(yōu)質(zhì)產(chǎn)品更多>
供貨周期 現(xiàn)貨 規(guī)格 1 mg
貨號(hào) tlrl-mpls 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
主要用途 科研
Synthetic lipid A
Synthetic lipid A from E. coli, serotype R515 (MPLAs) is a pure monophosphoryl lipid A compound produced by chemical synthesis.
MPLAs activates TLR4 but does not activate TLR2 refle…

Synthetic lipid A

Synthetic lipid A from E. coli, serotype R515 (MPLAs) is a pure monophosphoryl lipid A compound produced by chemical synthesis.
MPLAs activates TLR4 but does not activate TLR2 reflecting its high purity. MPLAs contains 6 fatty acyl groups, while MPLA purified from bacteria contains a mixture of 5, 6, and 7 acyl lipid A.

MPLA has been tested as an adjuvant in mice and reported to induce a strong Th1 response.

MPLAs VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile.

MPLAs VacciGrade™ is for research use only, not for use in humans.


Specifications

Specificity: TLR4 agonist - Th1 response

Working concentration: 2- 20 μg/mouse

Quality: Sterile

Molecular weight: 1763.47

CAS Number: 1246298-63-4

Solubility: 1 mg/ml in DMSO

Quality control:

  • MPLAs VacciGrade™ is a preclinical grade.

  • It is prepared under strict aseptic conditions.

  • MPLAs VacciGrade™ is guaranteed sterile.


Contents

MPLAs VacciGrade™ is provided as a clear, lipidic film.

  • 1 mg MPLAs VacciGrade™

  • 10 ml sterile endotoxin-free physiological water (NaCl 0.9%)

room temperature MPLAs VacciGrade™ is shipped at room temperature.

store Store at -20?C.

stable Product is stable 1 year when properly stored.

Upon resuspension, prepare aliquots of MPLAs VacciGrade™ and store at -20?C.

Resuspended product is stable 6 months when properly stored.

Avoid repeated freeze-thaw cycles.


Details

MPLA is a low-toxicity derivative of lipopolysaccharide (LPS), that retains the immunologically active lipid A portion of the parent molecule [1]. While the toxicity associated with LPS prohibits its potential clinical use, MPLA is being developed as a vaccine adjuvant [2]. Both LPS and MPLA are TLR4 agonists, but they signal through different adaptors, MyD88 and TRIF, respectively. The reduced toxicity of MPLA is attributed to the preferential recruitment of TRIF upon TLR4 activation, resulting in decreased induction of inflammatory cytokines [3].

MPLA has been tested as an adjuvant in mice and reported to induce a strong Th1 response [4-5]. Although the mechanism of action of MPLA has not been fully eludicated, it has been suggested that MPLA improves vaccine immunogenicity by enhancing antigen presenting cell maturation [6].

 

1. Okemoto K. et al., 2006. A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1. J Immunol. 176(2):1203-8.
2. Casella CR. et al., 2008. Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci. 65(20):3231-40.
3. Mata-Haro V. et al., 2007. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science. 316(5831):1628-32.
4. Fransen F. et al., 2007. Agonists of Toll-like receptors 3, 4, 7, and 9 are candidates for use as adjuvants in an outer membrane vaccine against Neisseria meningitidis serogroup. Infect Immun. 75(12) :5939-46.
5. Rhee EG. et al., 2010. TLR4 Ligands Augment Antigen-Specific CD8+ T Lymphocyte Responses Elicited by a Viral Vaccine Vector. J. Virol. 84: 10413 - 10419.
6. Didierlaurent A. et al., 2009. AS04, an aluminum salt- and TLR4 agonistbased adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J Immunol 183(10): 6186-97.


如需購買或咨詢?cè)摦a(chǎn)品技術(shù)問題,請(qǐng)聯(lián)系Invivogen一級(jí)代理商--欣博盛生物

會(huì)員登錄

×

請(qǐng)輸入賬號(hào)

請(qǐng)輸入密碼

=

請(qǐng)輸驗(yàn)證碼

收藏該商鋪

X
該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時(shí)間回復(fù)您~
撥打電話
在線留言
库伦旗| 荆门市| 平山县| 台中县| 邢台县| 咸宁市| 保山市| 察哈| 离岛区| 图木舒克市| 宁河县| 尤溪县| 马尔康县| 高要市| 都昌县| 云龙县| 永川市| 时尚| 庆安县| 康定县| 庆云县| 大理市| 温泉县| 新乐市| 台南市| 镇雄县| 堆龙德庆县| 洱源县| 铜鼓县| 衡水市| 安乡县| 科尔| 额尔古纳市| 平罗县| 苍南县| 阜平县| 乌海市| 杂多县| 香港 | 怀柔区| 大港区|