hCDH6/4T1 hCDH6/4T1 hCDH6/4T1
| I. Background | |||
| CDH6 （Cadherin 6,钙粘蛋白 6）是一种 II 型钙粘附素，是钙粘附素家族的成员之一。 CDH6 对于细胞黏附、胚胎发育的细胞识别、迁移和组织分化、构成成体器官都有重要作 用。在胚胎发育过程中，参与胚胎肾形态形成和发育，驱动肾形态发生所需的间充质-上皮 分化。CDH6 在甲状腺肿瘤、胆管癌、骨肉瘤、口腔鳞状细胞癌、黑色素瘤、甲状腺乳头 状癌、鼻咽癌、胶质瘤、胃癌等肿瘤中起到重要作用。CDH6 还可以作为甘氨酰-tRNA 合 成酶（GRS）的功能性受体在人体内部起到抗肿瘤作用。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hCDH6 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2μg/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
Figure 1. Recombinant hCDH6/4T1 stably expressing CDH6. | |||
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