Catalogue Number : 05121-77

Description

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

CD3產(chǎn)品描述：OKT3單克隆抗體的特異性反應(yīng)的CD3 / T淋巴細(xì)胞抗原受體復(fù)合物的ε鏈。CD3復(fù)合物含有γ，δ，和ε鏈，和它的TCR復(fù)雜的部分，由所有成熟T淋巴細(xì)胞和胸腺細(xì)胞系的表達(dá)。CD3增強(qiáng)的信號轉(zhuǎn)導(dǎo)的抗原識別。

PeproTech公司的BioGems產(chǎn)品OKT3抗體是一種免疫抑制，這已被證明是一種有效的治療劑，肝，心，腎移植排斥反應(yīng)。

Additional Information

Clone
OKT3
Format:
PE-Cy7
Applications
FC
Reactivity
Human

Isotype:
Mouse IgG2a, kappa
Research Interest: Adaptive Immunity
Cell Type: Treg cells, T Cells, NK and NKT Cells, Th17 cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.

Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... & A't Hart, B. (2009). A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. Journal of Histochemistry & Cytochemistry, 57(12), 1159-1167.

Anti-Human CD3 PE-Cy7
Technical Data Sheet
Catalogue Number : 05121-77
RUO: For Research Use Only. Not for use in diagnostic procedures.
Product Information
Clone: OKT3
Format/Conjugate: PE-Cy7
Concentration: 5 uL (0.5 ug)/test
Reactivity: Human
Laser: Blue (488nm)
Peak Emission: 785nm
Peak Excitation: 496nm
Filter: 780/60
Brightness (1=dim,5=brightest): 4
Isotype: Mouse IgG2a, kappa
Formulation: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Storage: Product should be kept at 2-8°C and protected from prolonged exposure to light.
Applications: FC
Description
The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The
CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and
by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and
renal allograft rejection.
Preparation & Storage
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Application Notes
The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. The antibody
can be used at less than or equal to 5 μL per test. A test is the amount of antibody required to stain a cell sample in
the final volume of 100 μL.

重慶市華雅干細(xì)胞技術(shù)有限公司代理的PeproTech公司旗下的BioGems產(chǎn)品，咨詢：

           :
References
1.Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
2.
Knapp W;(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
3.
Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... ; Jolliffe, L. K. (1994). Humanization of the murine
anti-human CD3 monoclonal antibody OKT3.;Human Antibodies,;5(1), 41-47.
4.
Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., ... ; A't Hart, B. (2009). A monoclonal antibody selection for
immunohistochemical examination of lymphoid tissues from non-human primates.;Journal of Histochemistry ; Cytochemistry,;57(12), 1159-1167.

PeproTech公司旗下的BioGems產(chǎn)品的其他相關(guān)信息如下：

Additional OKT3 Formats

Cat.No. Format Starting From
貨號：05121-20 Purified

貨號：05121-25 SAFIRE Purified

貨號：05121-40 BG Violet 450

貨號：05121-60 PE

貨號：05121-80 APC

貨號：05121-50 FITC

貨號：05121-70 PerCP-Cy5.5

貨號：05121-77 PE-Cy7

B7-H4 Human H74 Mouse IgG1, kappa SAFIRE (Functional) 100 μg 86611-25-100
B7-H5 Mouse 188 Rat IgG2b, kappa SAFIRE (Functional) 50 μg 86612-25-50
CD1a Human HI149 Mouse IgG1, kappa APC 100 tests 03111-80-100
CD1a Human HI150 Mouse IgG1, kappa Biotin 100 μg 03111-30-100
CD1a Human HI151 Mouse IgG1, kappa FITC 25 tests 03111-50-25
CD1a Human HI152 Mouse IgG1, kappa FITC 100 tests 03111-50-100
CD1a Human HI153 Mouse IgG1, kappa PE 25 tests 03111-60-25
CD1a Human HI154 Mouse IgG1, kappa PE 100 tests 03111-60-100
CD1a Human HI155 Mouse IgG1, kappa Purified 25 μg 03111-20-25
CD1a Human HI156 Mouse IgG1, kappa Purified 100 μg 03111-20-100
CD1d Mouse 1B1 Rat IgG2b, kappa SAFIRE (Functional) 100 μg 03112-25-100
CD1d Mouse 1B1 Rat IgG2b, kappa SAFIRE (Functional) 500 μg 03112-25-500
CD2 Human RPA-2.10 Mouse IgG1, kappa SAFIRE (Functional) 50 μg 04111-25-50
CD2 Human RPA-2.10 Mouse IgG1, kappa SAFIRE (Functional) 500 μg 04111-25-500
CD2 Mouse RM2-5 Rat IgG2b, lambda FITC 25 μg 04112-50-25
CD2 Mouse RM2-5 Rat IgG2b, lambda FITC 100 μg 04112-50-100
CD2 Mouse RM2-5 Rat IgG2b, lambda PE 25 μg 04112-60-25
CD2 Mouse RM2-5 Rat IgG2b, lambda PE 100 μg 04112-60-100
CD2 Mouse RM2-5 Rat IgG2b, lambda SAFIRE (Functional) 100 μg 04112-25-100
CD3 Human Hit3a Mouse IgG2a, kappa FITC 25 tests 05111-50-25
CD3 Human Hit3a Mouse IgG2a, kappa FITC 100 tests 05111-50-100
CD3 Human Hit3a Mouse IgG2a, kappa PE 25 tests 05111-60-25
CD3 Human Hit3a Mouse IgG2a, kappa PE 100 tests 05111-60-100
CD3 Human Hit3a Mouse IgG2a, kappa Purified 100 μg 05111-20-100
CD3 Human OKT3 Mouse IgG2a, kappa APC 25 tests 05121-80-25
CD3 Human OKT3 Mouse IgG2a, kappa APC 100 tests 05121-80-100
CD3 Human OKT3 Mouse IgG2a, kappa FITC 25 tests 05121-50-25
CD3 Human OKT3 Mouse IgG2a, kappa FITC 100 tests 05121-50-100
CD3 Human OKT3 Mouse IgG2a, kappa PE 25 tests 05121-60-25
CD3 Human OKT3 Mouse IgG2a, kappa PE 100 tests 05121-60-100
CD3 Human OKT3 Mouse IgG2a, kappa PerCP-Cy5.5 25 tests 05121-70-25
CD3 Human OKT3 Mouse IgG2a, kappa PerCP-Cy5.5 100 tests 05121-70-100
CD3 Human OKT3 Mouse IgG2a, kappa Purified 100 μg 05121-20-100
CD3 Human OKT3 Mouse IgG2a, kappa SAFIRE (Functional) 100 μg 05121-25-100
CD3 Human OKT3 Mouse IgG2a, kappa SAFIRE (Functional) 500 μg 05121-25-500
CD3 Human OKT3 Mouse IgG2a, kappa BG Violet 450 25 tests 05121-40-25
CD3 Human OKT3 Mouse IgG2a, kappa BG Violet 450 100 tests 05121-40-100
CD3 Human UCHT1 Mouse IgG1, kappa APC 25 tests 05131-80-25
CD3 Human UCHT1 Mouse IgG1, kappa APC 100 tests 05131-80-100
CD3 Human UCHT1 Mouse IgG1, kappa APC 500 tests 05131-80-500
CD3 Human UCHT1 Mouse IgG1, kappa APC-Cy7 25 tests 05131-87-25
CD3 Human UCHT1 Mouse IgG1, kappa APC-Cy7 100 tests 05131-87-100
CD3 Human UCHT1 Mouse IgG1, kappa Biotin 25 μg 05131-30-25
CD3 Human UCHT1 Mouse IgG1, kappa Biotin 100 μg 05131-30-100
CD3 Human UCHT1 Mouse IgG1, kappa FITC 25 tests 05131-50-25
CD3 Human UCHT1 Mouse IgG1, kappa FITC 100 tests 05131-50-100
CD3 Human UCHT1 Mouse IgG1, kappa FITC 500 tests 05131-50-500
CD3 Human UCHT1 Mouse IgG1, kappa PE-Cy7 25 tests 05131-77-25
CD3 Human UCHT1 Mouse IgG1, kappa PE-Cy7 100 tests 05131-77-100
CD3 Human UCHT1 Mouse IgG1, kappa PerCP-Cy5.5 25 tests 05131-70-25
CD3 Human UCHT1 Mouse IgG1, kappa PerCP-Cy5.5 100 tests 05131-70-100
CD3 Human UCHT1 Mouse IgG1, kappa Purified 100 μg 05131-20-100
CD3 Human UCHT1 Mouse IgG1, kappa SAFIRE (Functional) 100 μg 05131-25-100
CD3 Human UCHT1 Mouse IgG1, kappa SAFIRE (Functional) 500 μg 05131-25-500
CD3 Human UCHT1 Mouse IgG1, kappa BG Violet 450 25 tests 05131-40-25
CD3 Human UCHT1 Mouse IgG1, kappa BG Violet 450 100 tests 05131-40-100
CD3 Mouse 17A2 Rat IgG2b, kappa APC 25 μg 05112-80-25
CD3 Mouse 17A2 Rat IgG2b, kappa APC 100 μg 05112-80-100
CD3 Mouse 17A2 Rat IgG2b, kappa APC-Cy7 25 μg 05112-87-25
CD3 Mouse 17A2 Rat IgG2b, kappa APC-Cy7 100 μg 05112-87-100
CD3 Mouse 17A2 Rat IgG2b, kappa FITC 25 μg 05112-50-25
CD3 Mouse 17A2 Rat IgG2b, kappa FITC 100 μg 05112-50-100
CD3 Mouse 17A2 Rat IgG2b, kappa PE 25 μg 05112-60-25
CD3 Mouse 17A2 Rat IgG2b, kappa PE 100 μg 05112-60-100
CD3 Mouse 17A2 Rat IgG2b, kappa Purified 25 μg 05112-20-25
CD3 Mouse 17A2 Rat IgG2b, kappa Purified 100 μg 05112-20-100
CD3 Mouse 17A2 Rat IgG2b, kappa Purified 500 μg 05112-20-500
CD3 Mouse 17A2 Rat IgG2b, kappa SAFIRE (Functional) 100 μg 05112-25-100
CD3 Mouse 17A2 Rat IgG2b, kappa SAFIRE (Functional) 500 μg 05112-25-500
CD3 Mouse 17A2 Rat IgG2b, kappa BG Violet 450 25 μg 05112-40-25
CD3 Mouse 17A2 Rat IgG2b, kappa BG Violet 450 100 μg 05112-40-100
CD3 Rat G4.18 Mouse IgG3, kappa FITC 50 μg 05113-50-50
CD3 Rat G4.18 Mouse IgG3, kappa FITC 100 μg 05113-50-100
CD3 Rat G4.18 Mouse IgG3, kappa FITC 500 μg 05113-50-500
CD3 Rat G4.18 Mouse IgG3, kappa PE 50 μg 05113-60-50
CD3 Rat G4.18 Mouse IgG3, kappa PE 100 μg 05113-60-100
CD3 Rat G4.18 Mouse IgG3, kappa PE 200 μg 05113-60-200
CD3 Rat G4.18 Mouse IgG3, kappa SAFIRE (Functional) 500 μg 05113-25-500
CD3e Mouse 145-2C11 Armenian Hamster IgG APC 25 μg 05122-80-25
CD3e Mouse 145-2C11 Armenian Hamster IgG APC 100 μg 05122-80-100
CD3e Mouse 145-2C11 Armenian Hamster IgG Biotin 25 μg 05122-30-25
CD3e Mouse 145-2C11 Armenian Hamster IgG Biotin 100 μg 05122-30-100
CD3e Mouse 145-2C11 Armenian Hamster IgG FITC 25 μg 05122-50-25
CD3e Mouse 145-2C11 Armenian Hamster IgG FITC 100 μg 05122-50-100
CD3e Mouse 145-2C11 Armenian Hamster IgG FITC 500 μg 05122-50-500
CD3e Mouse 145-2C11 Armenian Hamster IgG PE 25 μg 05122-60-25
CD3e Mouse 145-2C11 Armenian Hamster IgG PE 100 μg 05122-60-100
CD3e Mouse 145-2C11 Armenian Hamster IgG PE 500 μg 05122-60-500
CD3e Mouse 145-2C11 Armenian Hamster IgG PE-Cy5 25 μg 05122-65-25
CD3e Mouse 145-2C11 Armenian Hamster IgG PE-Cy5 100 μg 05122-65-100
CD3e Mouse 145-2C11 Armenian Hamster IgG PE-Cy7 25 μg 05122-77-25
CD3e Mouse 145-2C11 Armenian Hamster IgG PE-Cy7 100 μg 05122-77-100
CD3e Mouse 145-2C11 Armenian Hamster IgG PerCP-Cy5.5 25 μg 05122-70-25
CD3e Mouse 145-2C11 Armenian Hamster IgG PerCP-Cy5.5 100 μg 05122-70-100
CD3e Mouse 145-2C11 Armenian Hamster IgG Purified 100 μg 05122-20-100
CD3e Mouse 145-2C11 Armenian Hamster IgG Purified 500 μg 05122-20-500
CD3e Mouse 145-2C11 Armenian Hamster IgG Purified 1 mg 05122-20-1000
CD3e Mouse 145-2C11 Armenian Hamster IgG SAFIRE (Functional) 100 μg 05122-25-100
CD3e Mouse 145-2C11 Armenian Hamster IgG SAFIRE (Functional) 500 μg 05122-25-500
CD3e Mouse 145-2C11 Armenian Hamster IgG SAFIRE (Functional) 1 mg 05122-25-1000
CD4 Human OKT4 Mouse IgG2b, kappa APC 25 tests 06111-80-25
CD4 Human OKT4 Mouse IgG2b, kappa APC 100 tests 06111-80-100
CD4 Human OKT4 Mouse IgG2b, kappa APC 500 tests 06111-80-500
CD4 Human OKT4 Mouse IgG2b, kappa FITC 25 tests 06111-50-25
CD4 Human OKT4 Mouse IgG2b, kappa FITC 100 tests 06111-50-100
CD4 Human OKT4 Mouse IgG2b, kappa FITC 500 tests 06111-50-500
CD4 Human OKT4 Mouse IgG2b, kappa PE 25 tests 06111-60-25
CD4 Human OKT4 Mouse IgG2b, kappa PE 100 tests 06111-60-100
CD4 Human OKT4 Mouse IgG2b, kappa PE 500 tests 06111-60-500
CD4 Human OKT4 Mouse IgG2b, kappa PerCP-Cy5.5 25 tests 06111-70-25
CD4 Human OKT4 Mouse IgG2b, kappa PerCP-Cy5.5 100 tests 06111-70-100
CD4 Human OKT4 Mouse IgG2b, kappa Purified 100 μg 06111-20-100
CD4 Human OKT4 Mouse IgG2b, kappa BG Violet 450 25 tests 06111-40-25
CD4 Human OKT4 Mouse IgG2b, kappa BG Violet 450 100 tests 06111-40-100
CD4 Human RPA-T4 Mouse IgG1, kappa APC 25 tests 06121-80-25
CD4 Human RPA-T4 Mouse IgG1, kappa APC 100 tests 06121-80-100
CD4 Human RPA-T4 Mouse IgG1, kappa APC 500 tests 06121-80-500
CD4 Human RPA-T4 Mouse IgG1, kappa APC-Cy7 25 tests 06121-87-25
CD4 Human RPA-T4 Mouse IgG1, kappa APC-Cy7 100 tests 06121-87-100
CD4 Human RPA-T4 Mouse IgG1, kappa FITC 25 tests 06121-50-25
CD4 Human RPA-T4 Mouse IgG1, kappa FITC 100 tests 06121-50-100
CD4 Human RPA-T4 Mouse IgG1, kappa FITC 500 tests 06121-50-500
CD4 Human RPA-T4 Mouse IgG1, kappa PE 25 tests 06121-60-25
CD4 Human RPA-T4 Mouse IgG1, kappa PE 100 tests 06121-60-100
CD4 Human RPA-T4 Mouse IgG1, kappa PE 500 tests 06121-60-500
CD4 Human RPA-T4 Mouse IgG1, kappa PerCP-Cy5.5 25 tests 06121-70-25
CD4 Human RPA-T4 Mouse IgG1, kappa PerCP-Cy5.5 100 tests 06121-70-100
CD4 Human RPA-T4 Mouse IgG1, kappa PE-Cy7 25 tests 06121-77-25
CD4 Human RPA-T4 Mouse IgG1, kappa PE-Cy7 100 tests 06121-77-100
CD4 Human RPA-T4 Mouse IgG1, kappa Purified 100 μg 06121-20-100
CD4 Human RPA-T4 Mouse IgG1, kappa BG Violet 450 25 tests 06121-40-25
CD4 Human RPA-T4 Mouse IgG1, kappa BG Violet 450 100 tests 06121-40-100
CD4 Mouse GK1.5 Rat IgG2b, kappa APC 25 μg 06112-80-25
CD4 Mouse GK1.5 Rat IgG2b, kappa APC 100 μg 06112-80-100
CD4 Mouse GK1.5 Rat IgG2b, kappa FITC 25 μg 06112-50-25
CD4 Mouse GK1.5 Rat IgG2b, kappa FITC 100 μg 06112-50-100
CD4 Mouse GK1.5 Rat IgG2b, kappa FITC 500 μg 06112-50-500
CD4 Mouse GK1.5 Rat IgG2b, kappa PE 25 μg 06112-60-25
CD4 Mouse GK1.5 Rat IgG2b, kappa PE 100 μg 06112-60-100
CD4 Mouse GK1.5 Rat IgG2b, kappa PE-Cy5 25 μg 06112-65-25
CD4 Mouse GK1.5 Rat IgG2b, kappa PE-Cy5 100 μg 06112-65-100
CD4 Mouse GK1.5 Rat IgG2b, kappa PE-Cy7 25 μg 06112-77-25
CD4 Mouse GK1.5 Rat IgG2b, kappa PE-Cy7 100 μg 06112-77-100
CD4 Mouse GK1.5 Rat IgG2b, kappa PerCP-Cy5.5 25 μg 06112-70-25