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产品英文名称: SB 431542
产品中文名称: SB 431542
SB 431542 产品英文简述:
SB 431542 is a selective inhibitor of the transforming growth factor-beta （TGF-beta） type I receptor activin receptor-like kinase ALK5 （IC50 = 94 nM）, and the related ALK4 and ALK7. 4-（5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL）-BENZAMIDE
Ref: Laping et al. Inhibition of transforming growth factor （TGF）-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol.Pharmacol. 62 58, 2002. Inman et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase （ALK） receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 62 65, 2002
?Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
?Biological Activity: Not determined.
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