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神经科学热门产品6：钾离子通道Blockers
阅读：1492 发布时间：2022-8-2
钾离子通道阻断剂（Potassium Channel Blockers），是一类可抑制K+通过膜通道的化合物，包括有机化合物和各类神经毒素（如α-Dendrotoxin，Apamin 等）
钾离子通道是四聚体的整合膜蛋白，形成水孔，K+可以通过水孔流动，并在许多生物体中发现。在神经元中，K+通道参与维持静息电位、动作电位后的膜复极、控制重复放电的时间。K+通道是生物体内广泛的离子转运分子，在人类体内有70多个基因编码不同的K+通道。
下表给大家带来三种针对不同钾离子通道的阻滞剂（Blocker）：电压门控钾离子通道抗体（Voltage-gated Ion Channel，简称Kv）、钙激活钾离子通道（Ca2+-Activated K+ Channels，简称KCa）、 内向整流型钾离子通道（Inward Rectifier K+ Channels，简称Kir）
电压门控离子通道Blocker
| 靶点通道 | 品名 | 货号 | 来源 |
| Various KV 离子通道 | ShK (Stichodactyla Toxin) | STS-400 | Synthetic peptide |
| Various KV 离子通道 | Stromatoxin-1 | STS-350 | Synthetic peptide |
| Various KV 离子通道 | Guangxitoxin-1E | STG-200 | Synthetic peptide |
| Various KV 离子通道 | 4-Aminopyridine | A-115 | Synthetic |
| A-type and Shaker-related | Pandinotoxin Kα | STP-500 | Synthetic peptide |
| Kv1.1, Kv1.2, Kv1.6 | α-Dendrotoxin | D-350 | Natural peptide |
| Kv1.1, Kv1.2 | β-Dendrotoxin | D-360 | Natural peptide |
| KV1.1, KV1.6，Kir1.1 | δ-Dendrotoxin | D-380 | Natural peptide |
| KV1.1, KV1.2 | γ-Dendrotoxin | D-370 | Natural peptide |
| KV1.1, KV1.2 | Dendrotoxin-K | D-400 | Natural peptide |
| KV1.1, KV1.2 | Dendrotoxin-I | D-390 | Natural peptide |
| KV1.1, KV1.2, KV1.3 | Hemitoxin | STH-500 | Synthetic peptide |
| KV1.1, KV1.2, KV1.3 | Hongotoxin-1 | RTH-400 | Recombinant, E. coli |
| KV1.1, KV1.2 | MCD peptide | STM-250 | Synthetic peptide |
| KV1.1, KV1.2, KV1.3, KCa3.1 | OsK-1 | RTO-150 | Recombinant, E. coli |
| KV1.2, KV1.3，KCa1.1 | Charybdotoxin | STC-325 | Synthetic peptide |
| KV1.2 | κ-Conotoxin RIIIJ | STC-660 | Synthetic peptide |
| KV1.2 | κ-Conotoxin RIIIK | STC-650 | Synthetic peptide |
| KV1.2 | Tityustoxin-Kα | STT-360 | Synthetic peptide |
| KV1.2, KV1.3 | Noxiustoxin | STN-340 | Synthetic peptide |
| KV1.3 | Aa1 Toxin | RTA-400 | Recombinant, E. coli |
| KV1.3 | ADWX-1 | STW-100 | Synthetic peptide |
| KV1.3 | Agitoxin-1 | RTA-150 | Recombinant, E. coli |
| KV1.3 | Agitoxin-2 | RTA-420 | Recombinant, E. coli |
| KV1.3 | Agitoxin-2-Cys-TAMRA | RTA-420-T | Recombinant, E. coli |
| KV1.3 | Agitoxin-3 | RTA-390 | Recombinant, E. coli |
| KV1.3 | HsTx1 | STH-300 | Synthetic peptide |
| KV1.3, KV1.6 | Margatoxin | STM-325 | Synthetic peptide |
| KV1.5, Kir2.3 | Carvedilol | C-180 | Synthetic |
| KV1.5, KV11.1 | Trimethylapigenin | T-145 | Synthetic |
| KV2 | Citalopram | C-195 | Synthetic |
| KV2 | Citalopram hydrobromide | C-185 | Synthetic |
| KV2.1 ,NaV1.5 | Jingzhaotoxin-III | STJ-200 | Synthetic peptide |
| KV2.1, NaV, CaV3.1, TRPA1 | ProTx-I | STP-400 | Synthetic peptide |
| KV3.4 , NaV | BDS-I | B-400 | Natural peptide |
| KV3.4 | BDS-II | B-450 | Natural peptide |
| KV4, TRPM3, TRPC5 | Rosiglitazone | R-125 | Synthetic |
| KV4 | Heteropodatoxin-2 | STH-340 | Synthetic peptide |
| KV4.1, NaV1.5 | Jingzhaotoxin-XII | STJ-100 | Synthetic peptide |
| Kv4.2, Kv4.3 ,NaV 离子通道 | Jingzhaotoxin-V | STJ-050 | Synthetic peptide |
| KV4.2, KV4.3 | Phrixotoxin-1 | P-710 | Natural peptide |
| KV4.2, KV4.3 | Phrixotoxin-2 | P-700 | Natural peptide |
| KV7 离子通道 | Linopirdine | L-155 | Synthetic |
| KV7 离子通道 | Linopirdine dihydrochloride | L-156 | Synthetic |
| KV7 离子通道 | XE991 | X-100 | Synthetic |
| KV7 离子通道 | XE991 dihydrochloride | X-101 | Synthetic |
| KV11.1 | BeKm-1 | RTB-470 | Recombinant, E. coli |
| KV11.1 | Dofetilide | D-100 | Synthetic |
| KV11.1 | E-4031 | E-500 | Synthetic |
| KV11.1 | Ergtoxin-1 | RTE-450 | Recombinant, E. coli |
| KV11.1 , NaV 离子通道 | GrTx1 | STG-250 | Synthetic peptide |
| KV11.1 channels, TTX-sensitive NaV | GsAF-I | STG-300 | Synthetic peptide |
| KV11.1 channels, TTX-sensitive NaV | GsAF-II | STG-350 | Synthetic peptide |
| KV11.1 , NaV1.3 离子通道 | Haplotoxin-2 | STT-200 | Synthetic peptide |
钙激活钾离子通道Blocker
| 靶点通道 | 品名 | 货号 | 来源 |
| KCa，NaV | Bupivacaine hydrochloride | B-125 | Synthetic |
| KCa | Paxilline | P-450 | Natural |
| KCa1.1, KV1.2, KV1.3 | Charybdotoxin | STC-325 | Synthetic peptide |
| KCa1.1 | Iberiotoxin | STI-400 | Synthetic peptide |
| KCa1.1，特定KV1 | Kaliotoxin-1 | STK-370 | Synthetic peptide |
| KCa1.1 | Penitrem A | P-650 | Natural |
| KCa1.1 | Slotoxin | RTS-410 | Recombinant, E. coli |
| KCa1.1 | Verruculogen | V-500 | Natural |
| KCa2 | Apamin | STA-200 | Synthetic peptide |
| KCa2 | Scyllatoxin | STS-370 | Synthetic peptide |
| KCa2 | Tamapin | STT-400 | Synthetic peptide |
| KCa3 and KV1.2 | Maurotoxin | STM-340 | Synthetic peptide |
| KV1.1, KV1.2, KV1.3, KCa3.1 | OsK-1 | RTO-150 | Recombinant, E. coli |
| KCa3.1 | TRAM 34 | T-105 | Synthetic |
内向整流型钾离子通道Blocker
| 靶点通道 | 品名 | 货号 | 来源 |
| Kir1.1 | Tertiapin-LQ | STT-220 | Synthetic modified peptide |
| Kir1.1 | Lq2 | RTL-550 | Recombinant, E. coli |
| Kir1.1, Kir3.2 | Tertiapin | STT-250 | Synthetic peptide |
| Kir1.1，KV1.1, KV1.6 | δ-Dendrotoxin | D-380 | Natural peptide |
| Kir1.1, Kir3.2 | Tertiapin-Q | STT-170 | Synthetic peptide |
| KV1.5, Kir2.3, adrenoceptors | Carvedilol | C-180 | Synthetic |
| KV4, TRPM3, TRPC5 | Rosiglitazone | R-125 | Synthetic |
带荧光标记的钾离子通道Blocker
| 靶点通道 | 品名 | 货号 | 荧光标记 | 来源 |
| Kir1.1, Kir3.2 | Tertiapin-Q-ATTO-488 | STT-170-AG | ATTO Fluor-488 | Synthetic peptide |
| Kir1.1, Kir3.2 | Tertiapin-Q-ATTO-633 | STT-170-FR | ATTO Fluor -633 | Synthetic peptide |
| KV1.2 | Tityustoxin-Kα (A20C)-ATTO-594 | STT-360-AR | ATTO Fluor -594 | Synthetic peptide |
关于Alomone
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