PD153035  153436-54-5

 PD153035
分子式：C16H14BrN3O2   分子量：360.21
 
产品描述
PD153035是一种有效的、选择性的、ATP竞争性的表皮生长因子受体酪氨酸激酶抑制剂
靶点
EGFR
 
       
IC50
25 pM
 
       
生物活性
An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035  in DMSO is also available.
溶解性
DMSO 10 mg/ml
稳定性
2年 -20°C粉状，6月-80°C溶于DMSO