Benserazide HCl14919-77-8鹽酸芐絲肼

鹽酸芐絲肼
分子式：   C10H15N3O5.HCl 分子量：293.71
 
產品描述
Benserazide 是一種外周性的芳香族L-氨基酸脫羧酶（AAAD）或DOPA脫羧酶抑制劑。
靶點
          
IC50
          
生物活性
Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor. It inhibits this decarboxylation, and since it itself cannot cross the blood-brain barrier, this allows dopamine to build up solely in the brain instead. Adverse effects caused by peripheral dopamine, such as nausea and arrhythmia, are minimized. However, benserazide cannot reduce the centrally-mediated side effects of levodopa, particularly dyskinesia.
溶解性
DMSO 59 mg/mL，水 59 mg/mL，乙醇 2 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO