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Monophosphoryl lipid A

CAS No. : 1246298-63-4

產(chǎn)品活性：Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine.

研究領域：Immunology/Inflammation

作用靶點：Toll-like Receptor (TLR)

In Vitro: Monophosphoryl lipid A (100 μg/ml, 2 hours; dendritic cells) induces NF-κB activation and modulates TLR2.
Monophosphoryl lipid A (5~100 μg/ml, 24 hours; dendritic cells) induces IL-12 production by human.
Increasing the amount of Monophosphoryl lipid A (from 0.1 to 1 μg), the percentage of matured BMDCs also increased. Monophosphoryl lipid A up-regulates dendritic cells surface markers. Monophosphoryl lipid A enhances T cell responses. Monophosphoryl lipid A (CD4 T cells) increases calcium mobilization of activated T cells.

In Vivo: The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice.

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