參考價	￥ 3000

生化試劑

MedChemExpress (M

純度	99.22%	分子量	522.31
分子式	C??H??ClN?O?.?/?HCl	供貨周期	現(xiàn)貨
規(guī)格	5 mg	貨號	HY-122181B
應用領域	醫(yī)療衛(wèi)生,化工,生物產業(yè),制藥/生物制藥

OTS186935 hydrochloride | MCEOTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells[1].

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OTS186935 hydrochloride

CAS No. :

產品活性：OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC₅₀ of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells.

研究領域：Epigenetics

作用靶點：Histone Methyltransferase

In Vitro: OTS186935 hydrochloride inhibits A549 cell growth with an IC₅₀ of 0.67 μM.

In Vivo: OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models.

相關產品：Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Reprogramming Compound Library | Anti-Blood Cancer Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | PRMT5-IN-17 | EZM0414 | BIX-01294 | WDR5-IN-5 | PRMT5-IN-22 | Gambogenic acid | SGC707 | Dot1L-IN-7 | MS1943 | PRMT5-IN-21 | NSD3-IN-3 | DCLX069 | MAK683 | DS-437 | EPZ020411 | WDR5-IN-4 TFA | Amodiaquine dihydrochloride | Furamidine | SMYD3-IN-2 | UNC0642 | Chaetocin | UNC0646 | UNC0224 | EBI-2511 | BVT948 | MM-401 | CMP-5 | EPZ-719

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