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Netropsin dihydrochloride

CAS No. : 18133-22-7

產(chǎn)品活性：Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus.

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶點(diǎn)：DNA/RNA Synthesis  |  Bacterial  |  Influenza Virus  |  Antibiotic  |  Orthopoxvirus

In Vitro: Netropsin dihydrochloride has potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner, it improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter.
Netropsin dihydrochloride in solutions of DNA has radioprotective ability against radiation-induced damage due to its high binding affinity and high structural stabilization, hydroxyl radical (OH*) generated by ionizing radiation cannot radiolyse the netropsin-DNA complex.

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