Renal Cell Carcinoma Marker 肾细胞癌标记

广州健仑生物科技有限公司

RCC在90％以上原发性肾细胞癌、 80％左右转移性肾细胞癌阳性表达。与CD10可联合用于转移性肾细胞癌的研究。RCC还表达于乳腺腺泡和导管上皮细胞的腔面、附睾上皮细胞及甲状旁腺主细胞内、甲状腺滤泡内的胶质。

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Renal Cell Carcinoma Marker 肾细胞癌标记

【产品介绍】

细胞定位：细胞浆/细胞膜

克隆号：66.4.C2

同型：IgG

适用组织：石蜡/冰冻

阳性对照：肾细胞癌/正常肾

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

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【公司名称】 广州健仑生物科技有限公司
【市场部】     欧

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

近日，来自牛津大学的科学家通过研究，揭示了控制机体上皮细胞形状和运动状态发生转变的关键机制，相关研究刊登于杂志Nature Cell biology上;文章中研究者表示，名为ASPP2的肿瘤抑制蛋白的功能就好比是一种分子开关，其可以控制并且逆转机体上皮细胞的形状及运动状态的改变，这对于解释一系列生化现象，比如伤口愈合、胚胎发育及癌症转移都非常关键。
研究者Xin Lu表示，目前我们尽力去鉴别出控制控制上皮细胞可塑性的分子开关，这样的可塑性是癌症的标志，为了发生转移，癌细胞会疏松自身的结构，不断摆动脱离母体肿瘤组织，进而在机体其它组织器官部位“安家”，上述的过程就称为上皮细胞向间充质细胞的转分化过程及间质细胞向上皮细胞的转化过程(EMT及MET)。
研究者发现，在肾小管的发育过程中ASPP2蛋白会促使MET过程的发生，从而过滤掉机体血液中的废弃物，而当ASPP2蛋白缺失时会促进EMT过程的发生，尤其是在表达常见癌症基因RAS细胞中，EMT过程尤为明显，从而就会引发癌症发生转移。随后研究人员对小鼠模型进行试验发现，当小鼠机体中抗原抗体癌细胞表达较低水平的ASPP2时，其就会大量转移至大脑细胞中，如果这些抗原抗体癌细胞表达较足量的ASPP2，其转移的能力就会明显下降。

Recently, scientists from Oxford University revealed the key mechanisms that control the change of the epithelial cell shape and movement in the body. Relevant research is published in the journal Nature Cell Biology. In the article, researchers said that the tumor suppressor protein called ASPP2 Is like a molecular switch that controls and reverses changes in the shape and motility of the body's epithelium, which is crucial for interpreting a range of biochemical phenomena such as wound healing, embryonic development, and cancer metastasis.
Xin Lu, a researcher, said that at present we try our best to identify molecular switches that control the plasticity of epithelial cells. Such plasticity is a hallmark of cancer. In order to metastasize, cancerous cells loose their structure and constantly swing away from the mother's tumor tissue, Other parts of the body organs "home", the above process is called the epithelial cells to mesenchymal cells transdifferentiation process and the conversion of stromal cells to epithelial cells (EMT and MET).
The researchers found that during the development of tubules, ASPP2 protein can promote the occurrence of MET process and thus filter out the body's blood waste, and when ASPP2 protein is missing, it can promote EMT process, especially in the expression of common cancer genes RAS cells, the EMT process is particularly evident, which will trigger the transfer of cancer. Subsequently, researchers conducted experiments on mouse models and found that when the antigen-antibody-expressing cancer cells in the mouse body express a lower level of ASPP2, they can be largely transferred to the brain cells. If these antigen-antibody-expressing cancer cells express a sufficient amount of ASPP2 , Its ability to transfer will be significantly reduced.