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目錄:愛必信(上海)生物科技有限公司>>抗體>>二抗>> abs131127Rabbit anti-Twist1 Polyclonal Antibody

Rabbit anti-Twist1 Polyclonal Antibody
  • Rabbit anti-Twist1 Polyclonal Antibody
參考價 800
訂貨量 ≥1
具體成交價以合同協(xié)議為準(zhǔn)
800
≥1
具體成交價以合同協(xié)議為準(zhǔn)
  • 品牌 absin
  • 型號 abs131127
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 上海市
屬性

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更新時間:2025-03-26 11:59:29瀏覽次數(shù):1227評價

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Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 th
概述
描述
Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
別名
Twist1抗體;ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; OTTHUMP00000116043; SCS; TWIST; Twist basic helix loop helix transcription factor 1; Twist family bHLH transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; TWIST1; TWST1_HUMAN;
宿主
Rabbit
特異性
The antibody detects endogenous levels of total Twist1 protein.
反應(yīng)種屬
Human;Mouse;Rat
應(yīng)用
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
免疫原
A synthesized peptide derived from Human TWIST1(Accession Q15672), corresponding to amino acid residues M1-P24.
性能
濃度
1mg/ml
純化方法
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
類型
Polyclonal Antibody
儲存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存儲溶液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
靶標(biāo)
背景說明
Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
組織特異性
Subset of mesodermal cells.
細(xì)胞定位
Nucleus;
UniProt
Q15672
實驗結(jié)果圖
Western blot analysis of extracts from JK, Raji and HL-60 cells using Twist1 Antibody
溫馨提示:本產(chǎn)品僅作科研實驗使用,不支持臨床等研究

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