仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用. Seribantumab （MM 121） is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor （ErbB） family members and its downstream signal. Seribantumab inhibits neuregulin 1 （NRG1） fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models